+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)



Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)



Journal of the Neurological Sciences 94(1-3): 79-100



Glial cytoplasmic inclusions (GCIs) were demonstrated by silver staining, immunocytochemistry and by electron microscopy in the central nervous system (CNS) of 11 patients with various combinations of striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome. Although their configuration in light microscope can sometimes resemble neurofibrillary tangles, their cellular localisation, measurements, ultrastructure, immunocytochemical characteristics and regional distribution all differ from these Alzheimer type changes. The majority of GCIs were localized in the white matter and appeared to be accompanied by an increase in the number of interfascicular oligodendroglial cells and pallor or loss of myelin staining. Our histological, ultrastructural and immunocytochemical findings all indicate that the cells which contain GCIs are oligodendrocytes and the inclusions themselves are composed of tubular structures. The presence of the until now unknown GCIs in all the 11 CNS, but not in age- and sex-matched control brains, indicates that GCI is a cellular change characteristic of multiple system atrophy and the three syndromes are various manifestations of the same disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040216431

Download citation: RISBibTeXText

PMID: 2559165

DOI: 10.1016/0022-510x(89)90219-0


Related references

Argyrophilic ubiquitinated cytoplasmic inclusions of Leu-7-positive glial cells in olivopontocerebellar atrophy (multiple system atrophy). Acta Neuropathologica 82(6): 488-493, 1991

Neuropathological background spinocerebellar degeneration with special reference to autonomic nervous system lesions in olivopontocerebellar atrophy shy drager syndrome and multiple system atrophy. Brain and Nerve 37(7): 675-685, 1985

Cytoplasmic oligodendroglial inclusions in a patient with striatonigral degeneration olivopontocerebellar atrophy and atypical picks disease. Neurobiology of Aging 11(3): 272-273, 1990

The distribution and dynamic density of oligodendroglial cytoplasmic inclusions (GCIs) in multiple system atrophy: A correlation between the density of GCIs and the degree of involvement of striatonigral and olivopontocerebellar systems. Acta Neuropathologica 93(6): 585-591, 1997

Glial cytoplasmic inclusions and tissue injury in multiple system atrophy: A quantitative study in white matter (olivopontocerebellar system) and gray matter (nigrostriatal system). Neuropathology 28(3): 249-257, 2008

Glial and neuronal cytoplasmic inclusions in familial olivopontocerebellar atrophy. Annals of Neurology 40(5): 819-820, 1996

Neuronal kinases in glial cytoplasmic inclusions in patients with multiple system atrophy. Rinsho Shinkeigaku 39(1): 13-15, 1999

Glial cytoplasmic inclusions of multiple system atrophy can be distinguished from glial inclusions in related disorders. Society for Neuroscience Abstracts 24(1-2): 1018, 1998

Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy. Brain Research 1136(1): 219-227, 2007

Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy. International Journal of Neuroscience 121(10): 543-550, 2011

Striatonigral degeneration and sporadic olivopontocerebeller atrophy: A consideration of the clinical entity of multiple system atrophy. Brain and Nerve 51(4): 305-312, 1999

Laryngeal stridor caused by Gerhardt's syndrome in olivopontocerebellar atrophy and a probable striatonigral degeneration. Anales Otorrinolaringologicos Ibero-Americanos 17(1): 5-10, 1990

Glial cytoplasmic inclusions in multiple system atrophy. Annals of Neurology 39(3): 416, 1996

Glial cytoplasmic inclusions in multiple system atrophy. Nihon Rinsho. Japanese Journal of Clinical Medicine 69(Suppl. 8): 180-184, 2011

Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathologica 106(3): 243-250, 2003