+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor



Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor



Journal of Virology 54(1): 1-6



The nucleotide sequence of a cloned cDNA copy of the mRNA coding for the hemagglutinin-neuraminidase of the paramyxovirus SV5 was determined. There was a single large open reading frame on the mRNA which encoded a protein of 565 amino acids with a molecular weight of 62,134. The deduced amino acid sequence indicated that the only major hydrophobic region in the protein sufficiently long to anchor the protein in the membrane is located near the N terminus (amino acids 18 to 36). It is suggested that, like the influenza virus neuraminidase, hemagglutinin-neuraminidase of paramyxoviruses is oriented with its N terminus inserted into the membrane.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040260335

Download citation: RISBibTeXText

PMID: 3973974


Related references

Hemagglutinin neuraminidase protein of the paramyxovirus simian virus 5 nucleotide sequence of the messenger rna predicts an amino terminal membrane anchor. Journal of Virology 53(4): 1-6, 1985

Nucleotide sequence of the gene encoding the Newcastle disease virus hemagglutinin-neuraminidase protein and comparisons of paramyxovirus hemagglutinin-neuraminidase protein sequences. Virus Research 7(3): 187-202, 1987

Fusion protein of the paramyxovirus simian virus 5: nucleotide sequence of mRNA predicts a highly hydrophobic glycoprotein. Proceedings of the National Academy of Sciences of the United States of America 81(21): 6706-6710, 1984

Complete nucleotide sequence of the hemagglutinin-neuraminidase (HN) mRNA of mumps virus and comparison of paramyxovirus HN proteins. Virus Research 12(1): 87-96, 1989

Involvement of the cytoplasmic domain of the hemagglutinin-neuraminidase protein in assembly of the paramyxovirus simian virus 5. Journal of Virology 73(10): 8703-8712, 1999

Human parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein: nucleotide sequence of mRNA and limited amino acid sequence of the purified protein. Journal of Virology 57(2): 481-489, 1986

Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase. Journal of Virology 67(6): 2972-2980, 1993

Roles for the cytoplasmic tails of the fusion and hemagglutinin-neuraminidase proteins in budding of the paramyxovirus simian virus 5. Journal of Virology 76(18): 9284-9297, 2002

Polarized apical targeting directed by the signal/anchor region of simian virus 5 hemagglutinin-neuraminidase. Journal of Biological Chemistry 272(44): 27598-27604, 1997

Expression at the cell surface of biologically active fusion and hemagglutinin/neuraminidase proteins of the paramyxovirus simian virus 5 from cloned cDNA. Proceedings of the National Academy of Sciences of the United States of America 82(22): 7520-7524, 1985

Studies on the size chemical composition and partial sequence of the neuraminidase from type a influenza viruses show that the n terminal region of neuraminidase is not processed and serves to anchor the neuraminidase in the viral membrane. Virology 119(1): 109-121, 1982

Membrane glycoproteins of Newcastle disease virus: nucleotide sequence of the hemagglutinin-neuraminidase cloned gene and structure/function relationship of predicted amino acid sequence. Glycoconjugate Journal 18(4): 283-289, 2001

Cloning and nucleotide sequence of Newcastle disease virus hemagglutinin-neuraminidase mRNA: identification of a putative sialic acid binding site. Virology 156(1): 12-24, 1987

Sequence characterization of the membrane protein gene of paramyxovirus simian virus 5. Virology 176(1): 234-243, 1990

Nucleotide sequence of the DNA encoding the 5'-terminal sequences of simian virus 40 late mRNA. Journal of Biological Chemistry 253(2): 612-620, 1978