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Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1



Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1



Toxicologic Pathology 17(4 Pt 2): 754-758



2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when given to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.

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Accession: 040260369

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PMID: 2626666


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