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Hematic infiltrates and the expression of HLA-DR antigens in naso-sinusoidal polyps of the fibrous type

Hematic infiltrates and the expression of HLA-DR antigens in naso-sinusoidal polyps of the fibrous type

Bollettino Della Societa Italiana di Biologia Sperimentale 66(11): 1073-1080

In this study fibrous nasal polyps, obtained from four patients, were analyzed by means of immunocytochemical methods for the presence of interstitial hematic cell infiltrate and HLA-DR molecule expression. This histologic type accounted for 36.4% of nasal polyps studied. Our results demonstrated that cells belonging to monocyte-macrophage lineage were mainly detected within fibrous and edematous zones (greater than 50%), whereas T cells were found within the subepithelial peripheral connective tissue (greater than 60%). Surface and gland epithelial cells appeared to be more intensely stained for HLA-DR molecules than nasal epithelium of normal subjects, thus indicating that the intensity of HLA-DR molecule expression correlated with the presence of a hematic cell infiltrate. Nasal polyps are a frequent pathology whose etiology has not yet been completely clarified. The present study provides additional information about the fibrous polyp structure and can support some speculations on the nasal polyp etiology.

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Accession: 040260696

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PMID: 2095817

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