+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hematic radio-immunologic monitoring of clonazepam: clinical-pharmacological evaluations in a group of epileptic patients

Hematic radio-immunologic monitoring of clonazepam: clinical-pharmacological evaluations in a group of epileptic patients

Rivista di Neurologia 49(3): 259-267

In a group of 22 epileptic patients under treatment with clonazepam (CNP) it has been evaluated the serum levels of CNP in a seried way for a period of several months, by a radio-immunological technique. Except for one patient, all the others were under politherapy. On the basis of the data obtained from this study we tried to evaluate the pharmachological action of CNP. Even if we found a good clinical efficacy of CNP with therapeutic ranges (from 19,57 +/- 10,98 ng/ml up to 60,16 +/- 31,18 ng/ml) we didn't find any correlation between the oral dose and serum level, taking into account also other parameters such as sex, pound and age. The Authors discuss the possible factors which may be thought involved in this lacking correlation.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040260699

Download citation: RISBibTeXText

PMID: 472616

Related references

Long-term supervised domiciliary EEG monitoring in epileptic patients employing radio telemetry and telephone telemetry. II. Radio telemetry system. Electroencephalography and Clinical Neurophysiology 57(6): 584-586, 1984

Long term supervised domiciliary electro encephalographic monitoring in epileptic patients employing radio telemetry and telephone telemetry 2. radio telemetry system. Electroencephalography & Clinical Neurophysiology 57(6): 584-586, 1984

Therapeutic and pharmacological monitoring in individualization of primidone monotherapy of epileptic patients. Zhurnal Nevropatologii i Psikhiatrii Imeni S S Korsakova 91(6): 34-38, 1991

Monitoring plasma concentrations of zonisamide and clonazepam in an epileptic attempting suicide by an overdose of the drugs. Current Therapeutic Research 43(3): 463-467, 1988

Clinical use and effect of Ro 5-4023 (clonazepam) in different forms of epileptic seizures. Acta Neurologica Scandinavica. Supplementum 53: 60-71, 1973

Clinical pharmacological studies of ethotoin in pediatric epileptic patients. Journal of Pharmacobio-Dynamics 13(4): S92, 1990

Plasma levels of di n propyl acetate and clonazepam in epileptic patients. International Journal of Clinical Pharmacology and Biopharmacy 15(9): 403-408, 1977

Neuro-psychiatric evaluation of Clonazepam (Ro 5-4023) in epileptic patients. Gaceta Medica de Mexico 106(5): 385-392, 1973

The effects of clonazepam on the plasma di phenyl hydantoin level in epileptic patients. Electroencephalography & Clinical Neurophysiology 43(4): 497, 1977

Tiaramide in the treatment of patients with respiratory insufficiency. Clinical and laboratory evaluations of a group of 60 patients. La Clinica Terapeutica 93(1): 47-77, 1980

Clinical significance of immunologic monitoring in septic patients. Zhonghua Shao Shang Za Zhi 32(2): 67-70, 2016

Improved selectivity for high-performance liquid chromatographic determination of clonazepam in plasma of epileptic patients. Journal of Chromatography B 719(1-2): 227-233, 1998

Clonazepam in the treatment of epilepsy. A controlled clinical trial in simple absences, bilateral massive epileptic myoclonus, and atonic seizures. Archives of Neurology 33(5): 322-325, 1976

Localization of epileptic focus by protracted monitoring of EEG by radio telemetry. Epilepsia 10(3): 420, 1969