+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hematologic changes in alpha-thalassemia



Hematologic changes in alpha-thalassemia



American Journal of Clinical Pathology 90(2): 193-196



Alpha-thalassemia is very common in Thailand. Interaction of the different types of alpha-thalassemia can lead to many alpha-thalassemia syndromes. In this study the authors compare the hematologic data of subjects with various alpha-thalassemia phenotypes. Designation of the genotypes was based on family study and DNA mapping. The results show that there are equivocal hematologic findings among those who have similar molecular defects, i.e., alpha-thalassemia-2 and hemoglobin (Hb) Constant Spring heterozygotes: alpha-thalassemia 1, homozygous alpha-thalassemia 2, and alpha-thalassemia 2/Hb Constant Spring. The severity of these alpha-thalassemia syndromes correlates with the alpha-globin gene expression calculated from the finding of Liebhaber (Liebhaber SA, et al. J Biol Chem 1986; 261:15327-15333).

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040260881

Download citation: RISBibTeXText

PMID: 2839974


Related references

Hematologic indices in alpha thalassemia and beta thalassemia traits interacting with total and partial glucose 6 phosphate dehydrogenase deficiency. IRCS (International Research Communications System) Medical Science Library Compendium 9(3): 238-239, 1981

Different hematologic phenotypes are associated with the leftward (-alpha 4.2) and rightward (-alpha 3.7) alpha+-thalassemia deletions. Journal of Clinical Investigation 79(1): 39-43, 1987

Interaction of an alpha(+)-thalassemia deletion with either a highly unstable alpha-globin variant (alpha2, codon 59, GGC-->GAC) or a nondeletional alpha-thalassemia mutation (AATAAA-->AATAAG): comparison of phenotypes illustrating "dominant" alpha-thalassemia. Hemoglobin 23(4): 325-337, 1999

Cut-Off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia. International Journal of Molecular Sciences 18(12):, 2017

Hematologic features of alpha thalassemia carriers. International Journal of Molecular and Cellular Medicine 1(3): 162-167, 2012

alpha-Thalassemia: prevalence and hematologic findings in American Blacks. Archives of Internal Medicine 142(7): 1280-1282, 1982

Influence of alpha-thalassemia on the hematologic expression of homozygote drepanocytosis. Archives Francaises de Pediatrie 44(7): 517-519, 1987

Hematologic and molecular characterization of a Sicilian cohort of alpha thalassemia carriers. Haematologica 91(3): 409-410, 2006

Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies. Blood 105(2): 443-452, 2005

Differences between two types of Hb H disease, alpha-thalassemia 1/alpha-thalassemia 2 and alpha-thalassemia 1/Hb constant spring. Birth Defects Original Article Series 23(5a): 309-315, 1987

Molecular and hematologic features of hemoglobin E heterozygotes with different forms of alpha-thalassemia in Thailand. Annals of Hematology 82(10): 612-616, 2003

Clinical and hematologic aspects of the X-linked alpha-thalassemia/mental retardation syndrome (ATR-X). American Journal of Medical Genetics 55(3): 288-299, 1995

Hematologic interactions of endotoxin, tumor necrosis factor alpha (TNF alpha), interleukin 1, and adrenal hormones and the hematologic effects of TNF alpha in Corynebacterium parvum-primed rats. Journal of Leukocyte Biology 45(6): 546-557, 1989

X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome: a new kindred with severe genital anomalies and mild hematologic expression. American Journal of Medical Genetics 55(3): 302-306, 1995

Thalassemia intermedia as a result of heterozygosis for beta 0 -thalassemia and alpha alpha alpha anti-3,7 genotype in a Brazilian patient. Brazilian Journal of Medical and Biological Research 36(6): 699-701, 2003