+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions

Molecular and Cellular Biology 12(4): 1755-1763

Irradiated mice reconstituted with bone marrow cells infected with a retrovirus carrying the bcr-abl oncogene of human chronic myeloid leukemia are subject to a range of neoplastic hematopoietic diseases, both myeloid and lymphoid. Comparison of DBA/2 and C57BL/6 mice has revealed a marked strain difference in susceptibility to the various tumor types. The present study, performed with BALB/c mice, indicates that the kinetics and nature of the induced disease can be modulated by the infection procedure, as well as the genetic background, and that retroviral regulatory sequences may influence the outcome. A distinctive clonal myeloproliferative disorder, somewhat akin to chronic myeloid leukemia but with prominent erythroid and mast cell components, as well as granulocytic excess, was characterized.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 040260922

Download citation: RISBibTeXText

PMID: 1312670

DOI: 10.1128/mcb.12.4.1755

Related references

The role of cytokines and chemokines in neurological disease induced by polytropic retrovirus infection in mice. Journal of Neurovirology 8(Suppl. 1): 61, 2002

Prevention of retrovirus-induced neurological disease by infection with a nonneuropathogenic retrovirus. Virology 206(1): 372-380, 1995

Isotype profiles induced in BALB/c mice during foot and mouth disease (FMD) virus infection or immunization with different FMD vaccine formulations. Vaccine 13(10): 953-960, 1995

MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. Journal of Virology 78(12): 6449-6458, 2004

Hematologic abnormalities in simian acquired immune deficiency syndrome a model of primate retrovirus induced disease. Clinical Research 34(1): 97A, 1986

Systemic murine cytomegalovirus infection of mice with retrovirus-induced immunodeficiency results in ocular infection but not retinitis. Ophthalmic Research 30(5): 295-301, 1998

Respiratory syncytial virus induced more serious infection and inflammation in nude mice than in BALB/c mice. PEDIATRICS 121(Suppl.): S126-S126, 2008

Differences in Susceptibility Balb/c-nu/nu Mice and Balb/c Mice to Equine Herpesvirus 9 Infection. 2013

A model for mixed virus disease: co-infection with Moloney murine leukemia virus potentiates runting induced by polyomavirus (A2 strain) in Balb/c and NIH Swiss mice. Virology 212(2): 356-366, 1995

B6PD-1 knockout mice show more pronounced activational and immunodeficiency disease parameters than prototypic susceptible B6 mice after infection with a murine retrovirus complex, LP-BM5. FASEB Journal 18(4-5): Abst 82 12, 2004

Retrovirus-induced lymphoproliferative disease in mice: role of humoral immunity in perinatally exposed mice. Immunobiology 194(4-5): 390-402, 1995

Susceptibility of BALB/c-nu/nu mice and BALB/c mice to equine herpesvirus 9 infection. Veterinary Pathology 51(3): 581-590, 2014

Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. International Immunology 18(1): 183-198, 2006

Experimental allergic orchitis in mice. V. Resistance to actively induced disease in BALB/cJ substrain mice is mediated by CD4+ T cells. Immunogenetics 32(1): 34-40, 1990