+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hepatic schistosomiasis and chronic active hepatitis

Hepatic schistosomiasis and chronic active hepatitis

Journal of the Egyptian Society of Parasitology 19(2 Suppl): 909-920

As part of an investigation of the possible role of autoimmune mechanisms in the development of chronic active hepatitis (CAH) in schistosomiasis, sera from 25 patients (Group I) with hepatic schistosomiasis without histological features of CAH and 5 patients (Group II) with CAH and intestinal mansoniasis, but without discernible hepatic infection, were examined for the presence of the liver membrane antibody (LMA) that is reportedly associated with the autoimmune variant of CAH. All patients were HBsAg-negative. Circulating LMA was found in 17 (68%) Group I and 3 (60%) Group II patients. Low titres of various organ-non-specific autoantibodies were found in about a third of all patients but these did not correlate with the presence of LMA. There was also no correlation between LMA and antibodies to the hepatitis B core antigen (anti-HBc), found in the sera of 67% of the patients, indicating that occult or recent past hepatitis B virus infection was not a factor in LMA production. Long-term follow-up of the Group I patients should reveal whether current LMA-positivity is related to eventual development of CAH in hepatic schistosomiasis.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040270391

Download citation: RISBibTeXText

PMID: 2507659

Related references

Expression of schistosomiasis mansoni antigen could confirm the frequent coexitance of hepatic schistosomiasis with chronic hepatitis C An immunohistochemical study including assessement of ICAM-1 and collagen IV among those cases in comparison to pure hepatic schistosomiasis. Virchows Archiv 439(3): 452, 2001

T-cell subsets in pure hepatic schistosomiasis versus mixed schistosomal chronic active hepatitis. Journal of the Egyptian Society of Parasitology 20(1 Suppl.)): 417-424, 1990

Karyometric computerized analysis of the hepatocytes in chronic persistent hepatitis, in active chronic hepatitis, and in hepatic cirrhosis. Pathologica 85(1100): 649-659, 1993

Active chronic hepatitis and decompensated schistosomiasis. Amb 24(11): 366-368, 1978

Computerized hepatocyte karyometry in chronic persistent hepatitis, chronic active hepatitis, and hepatic cirrhosis. Pathologica 85(1100): 649-659, 1993

Advanced hepatic schistosomiasis and chronic viral hepatitis. Amb 23(3): 75-78, 1977

Combined effect of hepatic schistosomiasis and chronic hepatitis on the liver of bilharzial patients. Journal of the Egyptian Society of Parasitology 20(1 Suppl.)): 441-445, 1990

Hepatic detoxification and hepatic function in chronic active hepatitis with and without cirrhosis. Digestive Diseases & Sciences 33(1): 41-46, 1988

Primary hepatic malignant lymphoma its occurrence in a patient with chronic active hepatitis cirrhosis and hepato cellular carcinoma associated with hepatitis viral infection. Cancer 46(2): 336-339, 1980

Significance of serum and hepatic markers of hepatitis B viral infection in HBsAg-positive and HBsAg-negative chronic active hepatitis. Hepatology 5(1): 50-53, 1985

HCV-related chronic active hepatitis with high titer anti-smooth muscle antibodies An entity to be distinguished from autoimmune chronic active hepatitis. Hepatology 18(4 Part 2): 249A, 1993

Idiopathic chronic active hepatitis and hepatic cell carcinoma. Acta Medica Scandinavica 211(3): 225-226, 1982

Ultrasound, hepatic lymph nodes and chronic active hepatitis. Journal of Hepatology 21(4): 578-581, 1994

Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin. Annals of Internal Medicine 92(1): 14-19, 1980

Secretion and hepatic removal of insulin in active chronic hepatitis. Diabetologia 23(2): 159, 1982