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Herpes simplex virus type 1 (HSV-1) HSZP interferes also after antibody neutralization with early shutoff of host protein synthesis induced by HSV-1 KOS

Matis, J.; Krivjanská, M.; Rajcáni, J.

Archives of Virology 123(1-2): 209-214

1992


ISSN/ISBN: 0304-8608
PMID: 1312822
DOI: 10.1007/bf01317150
Accession: 040275569

The HSZP strain of herpes simplex virus type 1 (HSV-1) is defective with respect to the early shutoff of host protein synthesis. However, in superinfection experiments using Vero cells, the HSZP strain was effective, even after neutralization by antibody, at interfering with the early shutoff function of the HSV-1 KOS strain. Evidence was given that the observed interference was not due to exclusion of the KOS by HSZP at the level of adsorption or penetration. The neutralized KOS strain failed to induce early shutoff of host protein synthesis.

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