Section 41
Chapter 40,276

Herpes simplex virus type 1 (HSV-1) HSZP interferes also heat inactivated with early shutoff of host protein synthesis induced by HSV-1 KOS

Matis, J.; Krivjanská, M.

Acta Virologica 32(5): 379-385


ISSN/ISBN: 0001-723X
PMID: 2904731
Accession: 040275570

The ability of two strains of herpes simplex virus type 1 (HSZP and KOS) to shut off the host protein synthesis in the presence of Actinomycin D was investigated. The HSZP strain proved to be defective with respect to the so-called early shutoff function. In superinfection experiments, the HSZP was effective at interfering with the early shutoff function of the KOS strain provided that the HSZP infection preceded KOS superinfection. Heat inactivation of the HSZP did not lead to the loss of its interfering ability. Evidence was given that this interference was neither due to the hindrance of the KOS by HSZP at adsorption nor due its exclusion during penetration.

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