+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum



Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum



Proceedings of the National Academy of Sciences of the United States of America 83(16): 6065-6069



Two genes encoding distinct histidine-rich proteins in a Plasmodium falciparum clone exhibit high levels of homology, suggesting they have originated by duplication and divergence from a common ancestral sequence. Both genes have a similar interrupted structure and an exon that encodes closely related tandem repeats of very high histidine and alanine content. The most common repeat encoded by one gene, the hexapeptide Ala-His-His-Ala-Ala-Asp, differs in the sixth position from the most common repeat encoded by the other gene, the hexapeptide Ala-His-His-Ala-Ala-Asn. The divergence of the repeat domains is greater than that of the flanking regions, which exhibit 85-90% homology, including untranslated sequences. This suggests the tandem repeats are relatively labile elements within the genome that may provide the parasite with a means of rapid evolutionary change.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040298659

Download citation: RISBibTeXText

PMID: 3016741

DOI: 10.2307/28096


Related references

Homologous sequences in Plasmodium cynomolgi and the gene of the histidine-rich knob protein of Plasmodium falciparum. Molecular and Biochemical Parasitology 38(2): 291-293, 1990

The Search for Plasmodium falciparum histidine-rich protein 2/3 Deletions in Zambia and Implications for Plasmodium falciparum histidine rich-protein 2-Based Rapid Diagnostic Tests. American Journal of Tropical Medicine and Hygiene 2019, 2019

Variation in Plasmodium falciparum Histidine-Rich Protein 2 (Pfhrp2) and Plasmodium falciparum Histidine-Rich Protein 3 (Pfhrp3) Gene Deletions in Guyana and Suriname. Plos One 10(5): E0126805, 2016

Deletion of Plasmodium falciparum Histidine-Rich Protein 2 (pfhrp2) and Histidine-Rich Protein 3 (pfhrp3) Genes in Colombian Parasites. Plos One 10(7): E0131576, 2016

Analysis of var genes cloned from a Plasmodium falciparum isolate in China. Asian Pacific Journal of Tropical Medicine 5(2): 85-90, 2012

Histidine rich protein genes and their transcripts in plasmodium falciparum and plasmodium lophurae. Molecular & Biochemical Parasitology 12(1): 85-94, 1984

Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 92(15): 7100-7104, 1995

In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II. Malaria Journal 18(1): 78, 2019

Histidine-rich protein genes and their transcripts in Plasmodium falciparum and P. lophurae. Molecular and Biochemical Parasitology 12(1): 85-94, 1984

Histidine-rich proteins in Plasmodium falciparum an update and perspective. UCLA (University of California Los Angeles) Symposia on Molecular and Cellular Biology New Series, 42: 47-58, 1987

Studies on expression of Plasmodium falciparum histidine-rich proteins II in Escherichia coli and identification of the expressed proteins. Chinese Journal of Zoonoses 15(1): 23-26, 1999

Cloning and sequencing of the genes coding for the histidine-rich protein II of Plasmodium falciparum. Chinese Journal of Parasitology and Parasitic Diseases 17(5): 277-281, 1999

Cloning and sequencing of the genes coding for the histidine-rich protein II of Plasmodium falciparum. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17(5): 277-281, 2003

Genetic variability of Plasmodium falciparum histidine-rich proteins 2 and 3 in Central America. Malaria Journal 18(1): 31, 2019

Localization and functional analysis of the Plasmodium falciparum membrane associated histidine-rich proteins 1 and 2 (MAHRP-1 and -2).. 2008