+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Identification and secretion of gamma-endorphin and beta-endorphin-like peptides from the neurointermediate pituitary of the rat



Identification and secretion of gamma-endorphin and beta-endorphin-like peptides from the neurointermediate pituitary of the rat



Progress in Clinical and Biological Research 192: 285-292



Gamma-endorphin (gamma E) and related peptides were chromatographically identified in extracts of neurointermediate (NIL) pituitary. When extracts of this tissue were purified and subjected to HPLC in order to identify gamma E-related peptides gamma E, des-tyrosine gamma E, des-enkephalin-gamma E, and alpha-N acetyl gamma E co-elutable peptides were evident. Perifusates of dispersed NIL tissue were also shown to contain beta E and gamma E-immunoreactivity, and the secretion of both was suppressed by exposure of the tissue to dopamine. This study provides evidence of the endogenous presence and secretion of pharmacologically active gamma E-related peptides by the intermediate lobe of the rat pituitary.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040339019

Download citation: RISBibTeXText

PMID: 2417252


Related references

Biosynthesis and release of beta-endorphin-, N-acetyl beta-endorphin-, beta-endorphin-(1-27)-, and N-acetyl beta-endorphin-(1-27)-like peptides by rat pituitary neurointermediate lobe: beta-endorphin is not further processed by anterior lobe. Journal of Neuroscience 1(6): 585-595, 1981

Isoproterenol-stimulated release of beta-endorphin and related peptides from the rat pituitary neurointermediate lobe in vitro: evidence for preferential release of certain molecular forms of beta-endorphin. Neuropeptides 17(2): 63-74, 1990

Gamma-Aminobutyric acid inhibits beta-endorphin secretion from the anterior pituitary but not the neurointermediate lobe in the rat. Endocrinology 118(1): 360-366, 1986

Regional distribution of gamma endorphin like and beta endorphin like peptides in the pituitary and brain of the rat. Peptides 2(Suppl. 1): 71-78, 1981

Localization and identification of gamma-endorphin and beta-endorphin-like peptides in the hypothalamus and ventral forebrain of the rat. Life Sciences 33(4): 337-345, 1983

Selective conversion of beta endorphin into peptides related to gamma endorphin and alpha endorphin. Nature (London) 283(5742): 96-97, 1980

Isoproterenol-stimulated release of β-endorphin and related peptides from the rat pituitary neurointermediate lobe in vitro: Evidence for preferential release of certain molecular forms of β-endorphin. Neuropeptides 17(2): 63-73, 1990

Autonomous beta-endorphin secretion from the pituitary neurointermediate lobe: in vivo studies. Life Sciences 34(16): 1605-1611, 1984

Identification of N alpha-acetyl-alpha-endorphin and N alpha-acetyl-gamma-endorphin isolated from the neurointermediate lobe of the rat pituitary gland. Journal of Biological Chemistry 260(11): 6663-6669, 1985

Beta-endorphin-related peptides in the human pituitary. Isolation and characterization of major immunoreactive peptides, including the formerly unrecognized peptide beta-endorphin 1-18. Acta Physiologica Scandinavica. Supplementum 531: 1-84, 1984

Distribution identification and secretion of gamma endorphin like peptides potential endogenous neuroleptics isolated from rat brain and pituitary. Drug Development Research 4(4): 445, 1984

Gamma-Endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients. Brain Research 376(1): 29-37, 1986

Identification of Na-acetyl-a-endorphin and Na-acetyl-c-endorphin isolated from the neurointermediate lobe of the rat pituitary gland. The Journal of Biological Chemistry 260: 63-9, 1985

In vitro modulation of beta endorphin secretion from rat neurointermediate pituitary after 6 hydroxydopamine induced degeneration of nerve terminals. Journal of Cell Biology 111(5 Part 2): 340A, 1990

Solid phase synthesis of porcine alpha endorphin and gamma endorphin 2 hypothalamic pituitary peptides with opiate activity. Biochemical and Biophysical Research Communications 74(1): 248-255, 1977