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Identification of cholera toxin-binding sites in the nucleus of intestinal epithelial cells



Identification of cholera toxin-binding sites in the nucleus of intestinal epithelial cells



Febs Letters 242(2): 309-313



Post-embedding immunogold electron microscopy shows several binding sites for cholera toxin in mouse intestinal epithelial cells, particularly in the heterochromatin of the nucleus as well as in the plasma membrane. Anti-ganglioside GM1 antibodies also bound to the nucleus, but did not interfere with the binding of toxin. 125I-labelled toxin bound specifically to a nuclear preparation from rabbit intestinal cells.

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Accession: 040341938

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PMID: 2914613

DOI: 10.1016/0014-5793(89)80491-0


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