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Improved method for the determination of indomethacin in plasma by reversed phase HPLC



Improved method for the determination of indomethacin in plasma by reversed phase HPLC



Il Farmaco; Edizione Pratica 41(9): 290-299



An improved method for the determination of indomethacin in plasma by reverse phase HPLC is described. The procedure is simple and rapid, as concern the extraction stage, allowing about 30 samples to be analysed in a working day; distinctive features of accuracy, precision and sensitivity are also shown in comparison with existing methods. The chomatographic procedure requires a .mu.-Bondapak C-18, 300 .times. 4 mm column and a mobile phase consisting of methanol- pH 7.0/phosphate buffer 0.04 M 54:46. The detection specificity was verified by means of on line spectrophotometric analysis on the eluted peaks from plasma samples.

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Accession: 040380504

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PMID: 3770158


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