+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

In-vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium kansasii to amoxycillin and ticarcillin in combination with clavulanic acid



In-vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium kansasii to amoxycillin and ticarcillin in combination with clavulanic acid



Journal of Antimicrobial ChemoTherapy 22(6): 863-866



The in-vitro susceptibility of Mycobacterium tuberculosis, M. bovis, and M. kansasii to amoxycillin alone and in combination with 2 mg/l of clavulanic acid was evaluated by broth dilution. The MIC90 of amoxycillin plus clavulanic acid was 4 mg/l compared with greater than 32 mg/l for amoxycillin alone when tested against M. tuberculosis (n = 27). M. bovis (n = 8) was the most susceptible species with an MIC90 of amoxycillin 8 mg/l, compared with 0.5 mg/l for the combination. M. kansasii (n = 6), with an MIC90 of 16 mg/l for amoxycillin plus clavulanic acid was more resistant than either M. tuberculosis or M. bovis. Ticarcillin plus clavulanic acid with an MIC90 of 32 mg/l was less active against M. tuberculosis (n = 28) than amoxycillin plus clavulanic acid. The addition of clavulanic acid to amoxycillin greatly improves its in-vitro activity against M. tuberculosis and M. bovis.

(PDF emailed within 0-6 h: $19.90)

Accession: 040398486

Download citation: RISBibTeXText

PMID: 3149633

DOI: 10.1093/jac/22.6.863


Related references

In vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae to ticarcillin in combination with clavulanic acid. Antimicrobial Agents and ChemoTherapy 31(1): 132-133, 1987

In vitro susceptibility of mycobacterium bovis mycobacterium tuberculosis and mycobacterium kansasii to amoxicillin clavulanate. Abstracts of the Annual Meeting of the American Society for Microbiology 88: 140, 1988

Infections with mycobacterium avium human mycobacterium bovis mycobacterium tuberculosis mycobacterium kansasii mycobacterium intracellulare mycobacterium xenopei. Lancet (7558): 36, 1968

Delayed type skin reactions in guinea pigs sensitized with various acid fast bacilli and tested with protoplasms from homologous and heterologous organisms mycobacterium tuberculosis mycobacterium balnei mycobacterium batteyi mycobacterium bovis mycobacterium kansasii. International Archives Of Allergy & Applied Immunology: 283-292, 1968

Monoclonal antibodies for the rapid differentiation of mycobacterium tuberculosis from mycobacterium bovis mycobacterium avium mycobacterium kansasii and mycobacterium xenopi. Abstracts of the Annual Meeting of the American Society for Microbiology 88: 139, 1988

In vitro activities of norfloxacin and ciprofloxacin against mycobacterium tuberculosis mycobacterium avium complex mycobacterium chelonei mycobacterium fortuitum and mycobacterium kansasii. Antimicrobial Agents & Chemotherapy 26(1): 94-96, 1984

Periodic acid-Schiff reaction stains Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium ulcerans, Mycobacterium chelonei (abscessus), and Mycobacterium kansasii. Archives of Pathology and Laboratory Medicine 109(8): 701-703, 1985

Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis. International Journal of Systematic and Evolutionary Microbiology 68(1): 324-332, 2017

Deoxyribonucleic Acid Relatedness Among Selected Strains of Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium bovis Bcg, Mycobacterium microti, and Mycobacterium africanum. International Journal of Systematic Bacteriology 35(2): 147-150, 1985

Susceptibility of multidrug-resistant strains of Mycobacterium tuberculosis to amoxycillin in combination with clavulanic acid and ethambutol. Journal of Antimicrobial ChemoTherapy 42(6): 735-740, 1999

Susceptibility of multidrug-resistant strains of Mycobacterium tuberculosis to amoxycillin in combination with clavulanic acid and ethambutol. Journal of Antimicrobial Chemotherapy 42(6): 735-740, 1998

In vitro activity of ciprofloxacin and ofloxacin against mycobacterium tuberculosis mycobacterium avium mycobacterium africanum mycobacterium kansasii and strains of bcg. Immunitaet und Infektion 14(6): 203-207, 1986

Immune responses in cattle inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii. Clinical and Vaccine Immunology 17(2): 247-252, 2010

Electron cytochemical study of cytochrome oxidase and peroxidase of mycobacterium leprae mycobacterium lepraemurium mycobacterium tuberculosis mycobacterium kansasii and mycobacterium balnei. International Journal Of Leprosy & Other Mycobacterial DiseasesSuppl.: 360-361, 1979

Direct detection of mycobacteria from bactec 12b bottles using commercially prepared chemiluminescent labeled nucleic acid probes for mycobacterium gordonae mycobacterium avium complex mycobacterium kansasii and mycobacterium tuberculosis. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 142, 1990