+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Increased calcium absorption in prehypertensive spontaneously hypertensive rat. Role of serum 1,25-dihydroxyvitamin D3 levels and intestinal brush border membrane fluidity

Increased calcium absorption in prehypertensive spontaneously hypertensive rat. Role of serum 1,25-dihydroxyvitamin D3 levels and intestinal brush border membrane fluidity

Journal of Clinical Investigation 78(4): 1083-1090

Changes in Ca absorption have been described in the spontaneously hypertensive rat (SHR) compared with Wistar-Kyoto (WKy) rats. In 3.5-wk-old SHR and age-matched WKy controls, we measured direct arterial blood pressure, Ca absorption, and serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] levels and small intestine brush border membrane (BBM) fluidity and lipid composition. The two objectives were (a) to define the nature of the absorptive changes before detectable hypertension and (b) to evaluate the potential mechanism(s). We found that even at this normotensive stage (106 +/- 4 vs. 107 +/- 2 torr for the female and 109 +/- 3 vs. 104 +/- 3 torr for the male), the SHR (a) absorbed more Ca (1.46 +/- 0.06 vs. 1.14 +/- 0.08 mmol/d and 1.53 +/- 0.06 vs. 1.28 +/- 0.06 mmol/d, respectively) and retained more Ca, (b) had higher serum 1,25(OH)2D3 levels (340 +/- 36 vs. 160 +/- 18 pg/ml and 230 +/- 25 vs. 150 +/- 16 pg/ml, respectively), and (c) possessed BBM with increased fluidity and with reduced fatty acyl saturation index owing to decreased stearic (32.2 +/- 2.6% vs. 38.2 +/- 0.9%) but increased linoleic acids (12.2 +/- 2.0% vs. 7.6 +/- 1.6%). These results demonstrate increased Ca absorption in prehypertensive SHR associated with increased serum 1,25(OH)2D3 levels, increased intestinal BBM fluidity, and reduced saturation index, which singly or in combination could produce the changes in intestinal Ca transport.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 040407136

Download citation: RISBibTeXText

PMID: 3760184

Related references

Increased intestinal and renal calcium transport by prehypertensive spontaneously hypertensive rat evidence for their primacy and the role of 1 25 dihydroxyvitamin d 3. Kidney International 29(1): 244, 1986

Reduced duodenal enterocyte calcium fluxes decreased 1 25 dihydroxyvitamin d3 and abnormal brush border membrane in the spontaneously hypertensive rat. Bronner, F And M Peterlik (Ed ) Progress in Clinical And Biological Research, Vol 252 Cellular Calcium And Phosphate Transport in Health And Disease; Third International Workshop on Calcium And Phosphate Transport Across Biomembranes, Vienna, Austria, March 1-4, 1987 Xxiii+426p Alan R Liss, Inc : New York, New York, Usa Illus 365-370, 1988

Increased brush-border membrane calcium transport in the intestine, but not the kidney tubule, of spontaneously hypertensive rats. American Journal of Hypertension 6(7 Pt 1): 593-601, 1993

Reduced intestinal epithelial cell brush border membrane calcium transport in spontaneously hypertensive rats. Journal of Hypertension 17(6): 777-784, 1999

The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Progress in Clinical and Biological Research 168: 193-198, 1984

Intestinal calcium transport in spontaneously hypertensive rat shr and their genetically matched wistar kyoto rat wky studies in brush border bbm and basolateral membrane blm. Gastroenterology 96(5 Part 2): A466, 1989

Lipid composition and fluidity in the jejunal brush-border membrane of spontaneously hypertensive rats: Effects on activities of membrane-bound proteins. Bioscience Reports 16(3): 217-226, 1996

Decreased intestinal calcium absorption in vivo and normal brush border membrane vesicle calcium uptake in cortisol treated chickens evidence for dissociation of calcium absorption from brush border vesicle uptake. Proceedings of the National Academy of Sciences of the United States of America 79(11): 3542-3546, 1982

Effects of dietary calcium deprivation on calcium absorption and serum 1 25 dihydroxyvitamin d 3 levels in young spontaneously hypertensive rats shr evidence for deranged regulation of vitamin d metabolism. Clinical Research 34(2): 541A, 1986

Increased calcium absorption in conscious pre hypertensive spontaneously hypertensive rat evidence against resistance to 1 25 dihydroxyvitamin d 3 in vivo. Clinical Research 33(2 Part 1): 430A, 1985

The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology 114(1): 260-267, 1984

Increased Na+-H+ exchanger activity in the ileal brush-border membrane of spontaneously hypertensive rats. Cmls Cellular & Molecular Life Sciences. 53(5): 442-446, 1997