+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Increased serum alpha 1-antitrypsin does not produce a rise in fecal alpha 1-antitrypsin in patients with healthy intestines



Increased serum alpha 1-antitrypsin does not produce a rise in fecal alpha 1-antitrypsin in patients with healthy intestines



Zeitschrift für Gastroenterologie 29(1): 11-15



Fecal alpha-1-Antitrypsin (alpha-1-AT) was related to serum alpha-1-AT concentration in 50 healthy controls, 51 patients with extraintestinal inflammatory disease as well as in 23 patients with ulcerative colitis with mild or severe disease activity. alpha-1-AT concentrations were measured by radial immunodiffusion. Even though serum alpha-1-AT concentration was elevated above normal limits in all patients, a concomitant increase of fecal alpha-1-AT was found only in patients with ulcerative colitis. In these patients a positive correlation between fecal alpha-1-AT-clearance and -concentration and severity and extension of inflammation could be demonstrated. It is concluded that elevated blood levels of alpha-1-AT do not cause increases in fecal alpha-1-AT loss and that fecal alpha-1-AT excretion is increased specifically in patients with intestinal inflammation.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040409948

Download citation: RISBibTeXText

PMID: 2058223


Related references

Elevated serum alpha 1 antitrypsin does not cause increased fecal alpha 1 at excretion in patients with normal bowel. Zeitschrift fuer Gastroenterologie 29(1): 11-15, 1991

Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing alpha 1-antitrypsin. Journal of Clinical Investigation 83(4): 1144-1152, 1989

The limitations of serum alpha-1 antitrypsin levels in patients with chronic liver disease and heterozygous alpha-1 antitrypsin deficiency. Gut 60(Suppl 1): A57-A58, 2011

Lack of effect of oral 4-phenylbutyrate on serum alpha-1-antitrypsin in patients with alpha-1-antitrypsin deficiency: a preliminary study. Journal of Pediatric Gastroenterology and Nutrition 39(1): 34-37, 2004

Long-term investigations of the alpha 1-antitrypsin content and in inhibiting capacity of the serum in patients with alpha 1-antitrypsin deficiency. Pneumonologie. Pneumonology 149(2): 157-166, 1973

Alpha-1-antitrypsin deficiency in children: liver disease is not reflected by low serum levels of alpha-1-antitrypsin - a study on 48 pediatric patients. European Journal of Medical Research 10(12): 509-514, 2005

Biochemical intermediates in alpha 1-antitrypsin deficiency: residual family resemblance for total alpha 1-antitrypsin, oxidized alpha 1-antitrypsin, and immunoglobulin E after adjustment for the effect of the Pi locus. Genetic Epidemiology 7(2): 137-149, 1990

Increased intestinal clearance of alpha 1-antitrypsin in patients with alpha 1-antitrypsin deficiency. Journal of Pediatric Gastroenterology and Nutrition 2(1): 95-98, 1983

Recombinant dna produced valine 358 alpha 1 antitrypsin more effectively resists oxidative inactivation by alveolar macrophages of cigarette smokers than plasma derived m 1m 1 alpha 1 antitrypsin or methionine 358 alpha 1 antitrypsin. American Review of Respiratory Disease 133(4 Suppl.): A218, 1986

Fecal concentration of alpha 1 antitrypsin cannot substitute for alpha 1 antitrypsin clearance as a marker of local activity in crohns disease. European Journal of Clinical Investigation 22(4 Part 2): A22, 1992

Alpha 1-antitrypsin Null(isola di procida): an alpha 1-antitrypsin deficiency allele caused by deletion of all alpha 1-antitrypsin coding exons. American Journal of Human Genetics 47(3): 403-413, 1990

Examinations on the determination and phenostandardization of alpha 1 antitrypsin in the serum of healthy newborn infants and children comparing them with children suffering from different diseases with deficiency in alpha 1 antitrypsin as well as mothers on the day of delivery comparing them with healthy women 18 35 years of age. Zeitschrift fuer Klinische Medizin 44(14): 1229-1232, 1989

Human neutrophils express the alpha 1-antitrypsin gene and produce alpha 1-antitrypsin. Blood 77(12): 2724-2730, 1991

Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy. American Review of Respiratory Disease 135(3): 539-543, 1987

Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals. Journal of Proteome Research 13(2): 596-605, 2014