Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction in man induced by secretin and cholecystokinin-pancreozymin administration

Creutzfeldt, W.; Lankisch, P.G.; Fölsch, U.R.

Deutsche Medizinische Wochenschrift 100(20): 1135-1138


ISSN/ISBN: 0012-0472
PMID: 1126301
Accession: 040442624

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Somatostatin (200 mug/h) was administered to five healthy volunteers after submaximal stimulation of exocrine pancreatic secretion with 0.33 KU secretin or cholecystokinin-pancreozymin, given intravenously. In all instances there was a significant reduction in duodenal secretory volume after secretin, without any change in HCO3- concentration. Stimulation of enzyme secretion by cholecystokinin-pancreozymin was significantly inhibited and gallbladder contraction abolished.