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Inhibition of cell proliferation in the thymus: possibility of detecting natural cell death within the organ and its contribution to the phenomenon of induced interphase cell death

Inhibition of cell proliferation in the thymus: possibility of detecting natural cell death within the organ and its contribution to the phenomenon of induced interphase cell death

Radiobiologiia 27(4): 468-472

Parallelism was noted between the suppression of proliferation and the amount of cells dying in mouse thymus after the effects inducing cell destruction. However, inhibition of DNA synthesis under the effect of nontoxic doses of arabinoside cytosine increased insignificantly the number of dying cells as compared to normal. This indicated the absence of the masking effect of reutilization of degradation products of dying cells, minor amounts of cells normally dying in the thymus, and their insignificant contribution to the induced cell death after the effects leading to inhibition of cell proliferation.

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Accession: 040444556

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PMID: 3628724

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