Inhibition of histamine-sensitive adenylate cyclase system of human gastric mucosa by cimetidine

Simon, B.; Kather, H.

Leber Magen Darm 7(6): 383-385

1977


ISSN/ISBN: 0300-8622
PMID: 593028
Accession: 040445946

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Abstract
Human gastric mucosa contains a histamin-sensitive adenylate cyclase system. The activation of this enzyme system by histamine is competititively inhibited by the H2-receptor blocking agent cimetidine. Our results underscore the rational basis for the use 0f H2-receptor antagonists in the therapy of peptic ulcer.