Section 41
Chapter 40,448

Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor

Johnson, R.J.; Raines, E.W.; Floege, J.; Yoshimura, A.; Pritzl, P.; Alpers, C.; Ross, R.

Journal of Experimental Medicine 175(5): 1413-1416


ISSN/ISBN: 0022-1007
PMID: 1569407
DOI: 10.1084/jem.175.5.1413
Accession: 040447022

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Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease.

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