+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of platelet function by contrast media: iopamidol and ioxaglate versus iothalamate. Work in progress



Inhibition of platelet function by contrast media: iopamidol and ioxaglate versus iothalamate. Work in progress



Radiology 156(2): 311-313



The effects of an ionic contrast agent, meglumine iothalamate (Conray-60), and two newer low-osmolality radiographic contrast media, sodium meglumine ioxaglate (Hexabrix) and iopamidol (B-15,000), on platelet aggregation and secretion responses were studied. All three agents inhibited platelet responses during stimulation with adenosine diphosphate (ADP), epinephrine, and collagen. Platelet function was inhibited by iothalamate at concentrations of 11 mg iodine/ml and above, and by the newer agents at concentrations above 30 mg iodine/ml. Addition of exogenous calcium decreased the iothalamate-induced inhibition of aggregation but did not improve dense granule secretion. There was no consistent effect of exogenous calcium on platelet inhibition by iopamidol and ioxaglate. These studies indicate that the newer agents inhibit platelet function less than iothalamate does, and that chelation of Ca2+ may not be the major mechanism of platelet inhibition by contrast agents.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040447955

Download citation: RISBibTeXText

PMID: 4011893

DOI: 10.1148/radiology.156.2.4011893


Related references

Comparison of low osmolality ionic (ioxaglate) versus nonionic (iopamidol) contrast media in cardiac angiography. American Journal of Cardiology 63(7): 489-495, 1989

Comparative effects on left ventricular function in coronary patients of various contrast media used in coronarography: iopamidol, diatrizoate, ioxaglate. Annales de Radiologie 26(8 Pt 2): 758-763, 1983

Contrast media in double-contrast arthrography of the knee: a comparison of ioxaglate and iothalamate preparations. British Journal of Radiology 59(698): 143-146, 1986

Effects of low osmolar contrast media, ioxaglate and iopamidol, on the erythrocyte membrane elasticity. Biorheology 32(2-3): 325-326, 1995

Effects of two low-osmolar contrast media, ioxaglate and iopamidol, on erythrocyte membrane elasticity. Investigative Radiology 29(12): 1026-1030, 1994

Blood gas pH and pulmonary response to the inhalation of low osmolar contrast media iopamidol and ioxaglate. Investigative Radiology 22(11): 908-911, 1987

Safety of contrast media in cerebral angiography: iopamidol vs. methylglucamine iothalamate. Ajnr. American Journal of Neuroradiology 5(6): 801-803, 1984

Low osmolality contrast media in peripheral arteriography clinical comparison of ioxaglate iopamidol iohexol and diatrizoate. Nippon Acta Radiologica 45(11): 1407-1420, 1985

Contrast media for cerebral arteriography clinical and radiological evaluation of iopamidol and iothalamate meglumine. Ajnr 5(5): 682, 1984

Contrast agent induced thrombophlebitis following leg phlebography: iopamidol versus meglumine iothalamate. British Journal of Radiology 57(675): 205-207, 1984

Comparison of side effects of contrast media used for investigations by computed tomography iothalamate diatrizoate iodamide iopamidol. Radiologe 24(10): 488-490, 1984

Comparison of the side effects of urographic contrast media (iothalamate, diatrizoate, iodamide, iopamidol) within the scope of a CT study. Der Radiologe 24(10): 488-490, 1984

Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function. Clinical Hemorheology and Microcirculation 32(3): 227-239, 2005

New Cardiovascular Contrast Media: Sodium Iothalamate (Angioconray) and Methylglucamine Iothalamate (Conray). Comparative Observations on Various Contrast Media in Angiocardiography. British Journal of Radiology 37: 568-580, 1964

V1. Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function (vol 35, pg 397, 2006). Clinical Hemorheology and Microcirculation 35(4): 529, 2006