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Inhibitory effect of intracranial injections of tachykinins on angiotensin-induced drinking in the cat



Inhibitory effect of intracranial injections of tachykinins on angiotensin-induced drinking in the cat



Pharmacology Biochemistry and Behavior 31(2): 493-497



The tachykinins eledoisin, substance P and kassinin were administered by pulse intracerebroventricular (ICV) injections to cats made thirsty by ICV angiotensin II, 100 ng per cat. Eledoisin, 100 ng per cat, produced an inhibition of drinking which was larger (56.0 vs. 45.2%) and lasted longer than that evoked by 400 ng per cat of substance P. Kassinin, 100 ng per cat, did not evoke any effect at all. The treatment with these peptides neither produced signs of discomfort nor induced any other behavioural alteration. The results of present experiments suggest that the antidipsogenic effect of tachykinins is a phenomenon of general interest among mammals.

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Accession: 040451283

Download citation: RISBibTeXText

PMID: 2469087

DOI: 10.1016/0091-3057(88)90379-6


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