+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibitory effect of neuropeptide Y on stimulated renin secretion of awake rats



Inhibitory effect of neuropeptide Y on stimulated renin secretion of awake rats



Clinical and Experimental Pharmacology and Physiology 19(4): 223-228



1. (1-36)-NPY is a vasoconstrictor peptide widely distributed in sympathetic nerve terminals. This peptide exerts an inhibitory action on renin release induced by various stimuli. Post-synaptic neuropeptide Y (NPY) receptors show a high affinity for (1-36)-NPY as well as for the agonist (Pro34)-NPY, while presynaptic receptors bind preferentially (13-36)-NPY. 2. This study was undertaken to assess whether the NPY induced renin suppression in awake normotensive rats infused with the beta-adrenoceptor stimulant isoproterenol is mediated by activation of pre- or post-synaptic receptors. 3. Non-pressor doses of (1-36)-NPY and (Pro34)-NPY markedly attenuated the renin secretion triggered by isoproterenol whereas (13-36)-NPY had no effect. This suggests that the effect of NPY on renin release is due to the stimulation of post-synaptic receptors. However it remains unknown whether NPY acts directly on juxtaglomerular cells or indirectly by modifying intraglomerular haemodynamics.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040451350

Download citation: RISBibTeXText

PMID: 1325309

DOI: 10.1111/j.1440-1681.1992.tb00442.x


Related references

Effect of neuropeptide y on stimulated renin secretion. Allen, J M And J I Koenig (Ed ) Annals Of The New York Academy Of Sciences, Vol 611 Central And Peripheral Significance Of Neuropeptide Y And Its Related Peptides; Conference, Baltimore, Maryland, Usa, April 2-4, Xiii+533p The New York Academy Of Sciences: New York, New York, Usa Illus 453-454, 1990

Effect of loading right atrial and ventricular receptors on stimulated AVP, ACTH, and renin secretion in awake dogs. American Journal of Physiology 268(4 Pt 2): R1069-R1077, 1995

Suppressing effect of neuropeptide y on renin secretion in rats with hyperreninemia. European Journal of Clinical Investigation 17(2 Part 2): A55, 1987

Calcium dependency of the inhibitory effect of antidiuretic hormone on in vitro renin secretion in rats. Journal of Physiology 315: 21-30, 1981

PYY potently inhibits pancreatic exocrine secretion mediated through CCK-secretin-stimulated pathways but not 2-DG-stimulated pathways in awake rats. Digestive Diseases & Sciences 46(1): 156-165, 2001

Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats. Scandinavian Journal of Gastroenterology 25(8): 853-858, 1990

Inhibitory effect of neurotensin on pentagastrin-stimulated gastric acid secretion in pylorus-ligated rats. Biochemical and Biophysical Research Communications 152(1): 231-236, 1988

Inhibitory effect of intravenous GABA antagonists on gastric acid secretion stimulated by secretagogues in rats. Japanese Journal of Pharmacology 49(2): 267-274, 1989

Canrenoate reversal of inhibitory effects of digoxin on basal and furosemide-stimulated renin secretion. Clinical Pharmacology and Therapeutics 32(1): 1-6, 1982

Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus. Regulatory Peptides. 65(2): 145-151, 1996

Evaluation of the inhibitory effect of circulating corticosteroids on circadian stimulated and stress induced secretion of ACTH in rats. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 179(3): 346-351, 1985

Anesthetic dependence of the inhibitory effect of neurotensin on pentagastrin-stimulated acid secretion in rats. A possible role for somatostatin. Life Sciences 48(4): 333-339, 1991

Normalization of renin secretion by neuropeptide Y in adrenalectomized rats with glucocorticoid-induced hypertension. Archives des Maladies du Coeur et des Vaisseaux 79(6): 879-881, 1986