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Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa

Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa

Toxicon 25(11): 1235-1239

The freshwater, bloom forming cyanobacterium (blue-green alga) Microcystis aeruginosa produces a peptide hepatotoxin which causes death accompanied by liver necrosis. We show here that the time and dose-dependent blebbing of isolated hepatocytes is accompanied by the activation of phosphorylase a, with no changes in cyclic AMP levels, and by glutathione (acid-soluble thiols) depletion. These results suggest that the disruption of cytoskeletal structures is accompanied by disturbances in cellular calcium homeostasis and by decreased protection against oxidative damage to the cells.

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Accession: 040455014

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PMID: 3124300

DOI: 10.1016/0041-0101(87)90142-5

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