Section 41
Chapter 40,475

Interleukin-2 enhances production in 24 hours of infectious human immunodeficiency virus type 1 in vitro by naturally infected mononuclear cells from seropositive donors

Todd, B.; Pope, J.H.; Georghiou, P.

Archives of Virology 121(1-4): 227-232


ISSN/ISBN: 0304-8608
PMID: 1759906
DOI: 10.1007/bf01316757
Accession: 040474582

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When peripheral blood mononuclear cells from HIV-1 seropositive patients were treated with rIL-2 in vitro a rapid increase of 2-12 fold in production of extracellular infectious HIV-1 occurred, in 6 of 9 experiments. Overall, the increase in the 9 experiments was significant (p less than 0.01) and provides more direct evidence for an enhancing role of IL-2 in naturally infected cells.

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