+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intra-arterial infusion of doxorubicin with degradable starch microspheres. Improvement of hepatic tumor drug uptake



Intra-arterial infusion of doxorubicin with degradable starch microspheres. Improvement of hepatic tumor drug uptake



Archives of Surgery 121(11): 1277-1281



Regional infusion chemotherapy delivers higher drug concentrations to the tumor than other methods and may decrease systemic drug levels. We evaluated the efficacy of degradable starch microspheres (DSMs) to further increase drug delivery to hepatic tumors. Rabbits implanted with hepatic Vx-2 tumors were treated with hepatic arterial infusion of doxorubicin hydrochloride labeled with carbon 14 with and without DSMs. Tissue levels of doxorubicin were measured in the heart, liver, and tumor 30 minutes after drug infusion. Blood drug levels, as well as biliary and renal excretion rates of doxorubicin, were determined. In rabbits receiving the drug alone, doxorubicin uptake by the tumor and liver were 17.1 +/- 12.8 and 55.3 +/- 9.5 nmol/g of wet weight tissue (mean +/- SD), respectively. In rabbits receiving doxorubicin mixed with DSMs, the tumor and hepatic drug levels were 59.7 +/- 24.9 and 50.7 +/- 4.8 nmol/g, respectively. The tumor drug level was significantly higher in the group that received DSMs compared with the group that received only the drug; the hepatic drug uptake was unchanged. Peak blood and cardiac drug levels were decreased by the coinfusion of drug and DSMs, suggesting that tumor response rates may be improved and systemic toxicity diminished by the use of DSMs in regional infusion chemotherapy.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040484457

Download citation: RISBibTeXText

PMID: 3778200


Related references

Regional hepatic arterial infusion of degradable starch microspheres increases fluorodeoxyuridine (FUdR) tumor uptake. Surgery 105(3): 383-392, 1989

Hepatic intra-arterial administration of doxorubicin and degradable starch microspheres: A pharmacokinetic study in the rat. Acta Oncologica 33(1): 39-42, 1994

Case report of a liver metastasis from rectal cancer achieving complete response (CR) by a combination of intra-hepatic arterial infusion of irinotecan (CPT-11) with degradable starch microspheres (DSM) and weekly high-dose intra-hepatic arterial chemotherapy with 5-FU. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 33(10): 1485-1488, 2006

Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: a study in CC-531 liver tumor-bearing WAG RIJ rats. Anticancer Research 31(1): 153-159, 2011

Clinical trial of degradable starch microspheres dsm in the treatment of hepatic malignancies by intra arterial infusion of anticancer drugs relationship between quantity of dsm and blockade of arterial blood flow. Nippon Acta Radiologica 46(11): 1259-1266, 1986

A case report of intra-hepatic arterial infusion of mitomycin C with degradable starch microspheres for liver metastases of sigmoid colon carcinoma. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 29(12): 2080-2083, 2002

Three cases of multiple liver metastases of carcinoid tumor responding to hepatic arterial infusion chemotherapy using degradable starch microspheres. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 29(12): 2358-2361, 2002

Effects of verapamil and degradable starch microspheres during hepatic artery infusion of doxorubicin. Surgery 107(5): 552-559, 1990

Comparative clinical study in metastatic liver cancer between intra-arterial infusion of mitomycin C alone and intra-arterial infusion of mitomycin C combined with PJ-203 (degradable starch microspheres). Gan to Kagaku Ryoho. Cancer and ChemoTherapy 20(13): 2027-2035, 1993

Redistribution of hepatic arterial blood flow after arterial infusion of microspheres of degradable starch in patients with hepatic metastases from colorectal carcinoma. Bollettino Della Societa Italiana di Biologia Sperimentale 61(5): 755-762, 1985

Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. an animal study in CC-531 liver tumor-bearing rats. Anticancer Research 31(1): 147-152, 2011

Hepatic arterial infusion of mitomycin C with degradable starch microspheres for unresectable intrahepatic cholangiocarcinoma. Clinical Oncology ) 20(3): 241-246, 2008

Hepatic arterial infusion of degradable starch microspheres (DSM) with adriamycin or mitomycin C in liver cancer. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 15(8 Pt 2): 2640-2645, 1988