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Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1

Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1

Molecular and Cellular Biology 10(7): 3824-3827

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

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Accession: 040503452

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PMID: 2192264

DOI: 10.1128/mcb.10.7.3824

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