+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization



Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization



Scandinavian Journal of Gastroenterology 27(5): 381-387



Islet amyloid peptide (IAPP) or amylin is a recently discovered polypeptide without settled physiology in man. We present a patient with an endocrine pancreatic tumor secreting huge amounts of IAPP-like immunoreactivity (20,000 mol/l) and a concomitant development of diabetes mellitus. The release of insulin and pancreatic polypeptide (PP) was totally absent after an oral glucose load and a mixed meal, respectively. Tumor secretion of IAPP-like immunoreactivity seemed to be influenced by cholinergic mechanisms and by nutrients. The observed effects on insulin and PP secretion by high circulating levels of IAPP-like immunoreactivity may be of beneficial value for further studies of the physiology of IAPP in man.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040514622

Download citation: RISBibTeXText

PMID: 1326785

DOI: 10.3109/00365529209000092


Related references

Presence of islet amyloid polypeptide in rat islet B and D cells determines parallelism and dissociation between rat pancreatic islet amyloid polypeptide and insulin content. Biochemical and Biophysical Research Communications 182(2): 886-893, 1992

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proceedings of the National Academy of Sciences of the United States of America, 93(8): 3492-3496, 1996

Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid. Diabetes 48(10): 1962-1970, 1999

Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice. Regulatory Peptides 113(1-3): 89-94, 2003

Formation of islet amyloid in pancreatic islets from transgenic mice expressing human islet amyloid polypeptide. Clinical Science 87(1): 39P, 1994

Pancreatic islet cell tumor producing vasoactive intestinal polypeptide and calcitonin. Anticancer Research 17(6d): 4667-4670, 1998

Differential expression of rat pancreatic islet Beta-cell glucose transporter (GLUT 2), proinsulin and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycaemia and dexamethasone treatment. Diabetologia 35(12): 1125-1132, 1992

Unaltered pancreatic islet blood perfusion in islet amyloid polypeptide-deficient mice. European Journal of Endocrinology 146(1): 107-112, 2002

Expression of islet amyloid polypeptide in fetal and adult porcine and human pancreatic islet cells. Endocrinology 138(4): 5319-5325, 1997

Altered islet amyloid polypeptide storage in islet beta cells in diabetes associated with pancreatic carcinoma. Digestion 52(2): 111-112, 1992

Expression of islet amyloid polypeptide in fetal and adult porcine and human pancreatic islet cells. Endocrinology 137(12): 5319-5325, 1996

Islet amyloid polypeptide iapp is found in pancreatic islet hyperplasia and insulinomas of man and experimental animal models. Journal of Pathology 160(2): 155A, 1990

Islet amyloid polypeptide is expressed in the pancreatic islet parenchyma of the teleostean fish, Myoxocephalus (cottus) scorpius. Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 133B(1): 119-125, 2002

Pancreatic islet blood flow in the rat after administration of islet amyloid polypeptide or calcitonin gene-related peptide. Diabetes 43(3): 454-458, 1994

Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo. Lipids in Health and Disease 17(1): 42, 2018