+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Isolated, blood-perfused canine arteries: different vasoconstrictor responses of internal and external carotid arteries to 5-hydroxytryptamine



Isolated, blood-perfused canine arteries: different vasoconstrictor responses of internal and external carotid arteries to 5-hydroxytryptamine



Tohoku Journal of Experimental Medicine 125(1): 39-43



Canine carotid arteries were isolated, suspended in a bath and perfused under a constant flow rate with arterial blood led from a support dog. Resting perfusion pressure was set at a constant level over 50 mm Hg. Drugs were administered into the endothelial side of the artery through a cannulated tubing and the response was obtained as pressure changes. This preparation was proved to be superior to usual isolated arterial strips, since its reactivity was kept in a stable condition over 5-10 hours at 37 degrees C. Using this preparation, effects of 5-hydroxytryptamine (5-HT) on the internal and external carotid arteries were investigated in comparison with effects of norepinephrine. In the internal carotid artery, 5-HT caused a much more potent vasoconstriction than norepinephrine. On the other hand, in the external carotid artery, 5-HT caused only slight vasoconstriction, while norepinephrine produced a marked vasoconstriction.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040516827

Download citation: RISBibTeXText

PMID: 675675

DOI: 10.1620/tjem.125.39


Related references

Vasoconstrictor mechanism of 5-hydroxytryptamine in isolated and perfused canine basilar arteries. Archives Internationales de Pharmacodynamie et de Therapie 286(1): 111-122, 1987

Comparison of the vascular effects of adenosine, AMP, ADP and ATP on isolated blood-perfused internal and external carotid arteries of dogs. Clinical and Experimental Pharmacology and Physiology 7(2): 195-198, 1980

Difference in vasoconstrictor responses of the internal and external carotid arteries to norepinephrine. Nihon Heikatsukin Gakkai Zasshi 21(4): 274-276, 1985

Vasoconstrictor responses of isolated and perfused canine mesenteric arteries to alpha-adrenoceptor agonists. Archives Internationales de Pharmacodynamie et de Therapie 271(2): 241-248, 1984

Responses of isolated and perfused canine intermediate auricular arteries to 5 hydroxytryptamine and norepinephrine. Japanese Journal of Pharmacology 39(Suppl.): 352P, 1985

Potentiating effects of extraluminal oxyhemoglobin to intraluminal 5-hydroxytryptamine in isolated canine internal carotid arteries. Journal of Neurosurgery 69(2): 263-268, 1988

Endothelium-released adenosine triphosphate contributes to vasoconstrictor responses to periarterial nerve stimulation in isolated, perfused canine splenic arteries. Heart and Vessels 13(5): 256-261, 1998

Endothelium-released adenosine triphosphate contributes to vasoconstrictor responses to periarterial nerve stimulation in isolated, perfused canine splenic arteries. Heart and Vessels 13(5): 256-261, 1998

Blocking Effects of Nipradilol on Vasoconstrictor Responses to Periarterial Nerve Stimulation and α-Adrenoceptor Agonists in Isolated and Perfused Canine Mesenteric Arteries. Pharmacology 35(2): 112-120, 1987

Blocking effects of nipradilol on vasoconstrictor responses to periarterial nerve stimulation and alpha-adrenoceptor agonists in isolated and perfused canine mesenteric arteries. Pharmacology 35(2): 112-120, 1987

Mechanism of vascular responses to 5 hydroxytryptamine in isolated and perfused canine basilar arteries during the early stage of experimental subarachnoid hemorrhage. Wilkins, Rd. . Cerebral Vasospasm; Research Conference, Charlottesville, Virginia, Usa, April 29-May 1, . Xxi 522p. Raven Press, Ltd: New York, New York, Usa. Illus. 105-112, 1988

Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood. Acta Neurochirurgica 138(9): 1109-1117, 1996

Relationship between extraluminal oxyhemoglobin and endothelium-dependent vasodilatation in isolated perfused canine internal carotid arteries. Neurosurgery 23(2): 158-161, 1988

Redistribution of flow between canine isolated internal and external carotid arteries by vasoactive substances. Japanese Journal of Physiology 34(3): 457-468, 1984

Differential blood flow responses to CO₂ in human internal and external carotid and vertebral arteries. Journal of Physiology 590(14): 3277-3290, 2012