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Kinetics of IgM and IgG responses to Japanese encephalitis virus in human serum and cerebrospinal fluid

Burke, D.S.; Nisalak, A.; Ussery, M.A.; Laorakpongse, T.; Chantavibul, S.

Journal of Infectious Diseases 151(6): 1093-1099

1985


ISSN/ISBN: 0022-1899
PMID: 2987367
DOI: 10.1093/infdis/151.6.1093
Accession: 040539075

We measured levels of antibodies to Japanese encephalitis virus (JEV) in serum and in cerebrospinal fluid (CSF) specimens obtained from 32 patients with acute encephalitis by using "antibody-capture" solid-phase enzyme-linked immunoassays specific for IgM or IgG to JEV. The proportions of confirmed cases with IgM to JEV detectable in CSF were 68% (obtained on day 1), 100% (day 7), 96% (day 30), and 72% (day 180). For IgG in CSF the proportions were 47% (day 1), 89% (day 7), 100% (day 30), and 100% (day 180). Twenty-five CSF samples were obtained from control patients with other diseases with possible nervous system involvement (but none with a clinical diagnosis of viral encephalitis); none had detectable IgM to JEV. Five JEV-infected but asymptomatic siblings of patients with encephalitis were also examined; all had high levels of IgM to JEV in serum, but none had detectable IgM to JEV in CSF.

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