+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose



Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose



Human and Experimental Toxicology 10(1): 59-62



A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.

(PDF emailed within 0-6 h: $19.90)

Accession: 040574184

Download citation: RISBibTeXText

PMID: 1673626

DOI: 10.1177/096032719101000110


Related references

Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill. Journal of Clinical Psychopharmacology 13(2): 128-132, 1993

Torsades de pointes ventricular tachyarrhythmia associated with haloperidol. Journal of Clinical Psychopharmacology 6(6): 375-376, 1986

"Les torsades de pointes": an unusual ventricular arrhythmia. Annals of Internal Medicine 93(4): 578-584, 1980

Torsades de pointes ventricular tachycardia associated with overdose of astemizole. Mayo Clinic Proceedings 69(6): 589-593, 1994

Torsades de pointes arrhythmia in a patient with left ventricular myxoma. Chest 105(6): 1876-1878, 1994

Life-threatening Torsades de Pointes resulting from "natural" cancer treatment. Clinical Toxicology 47(6): 592-594, 2009

Hypocalcemia Presenting as Life Threatening Torsades de Pointes with Prolongation of QTc Interval. Indian Journal of Clinical Biochemistry 33(2): 235-238, 2018

A type 2 ryanodine receptor variant associated with reduced Ca 2+ release and short-coupled torsades de pointes ventricular arrhythmia. Heart Rhythm 14(1): 98-107, 2016

Life threatening torsades de pointes due to abiraterone-induced hypokaelemia in a patient with metastatic prostate cancer. New Zealand Medical Journal 129(1445): 124-127, 2017

A normal response to programmed stimulation does not preclude the occurrence of life-threatening torsades de pointes with sotalol. European Heart Journal 9(4): 458, 1988

An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6): 631-644, 2008

Life-threatening Torsade de Pointes Arrhythmia Associated with Head Injury. Neurosurgery 23(1): 89-92, 1988

Life-threatening torsade de pointes arrhythmia associated with head injury. Neurosurgery 23(1): 89-92, 1988

Risk of torsades de pointes with non-cardiac drugs. Grapefruit juice is source of potentially life threatening adverse drug reactions. BMJ 322(7277): 47, 2001

Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium. Heart Rhythm 10(10): 1516-1524, 2014