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Local antitumor activity of a primary and an anamnestic response to a syngeneic guinea pig hepatoma



Local antitumor activity of a primary and an anamnestic response to a syngeneic guinea pig hepatoma



Journal of the National Cancer Institute 55(4): 989-994



After intradermal (id) injection, the line-10 hepatoma grew progressively in nonimmune guinea pigs, whereas the line-1 hepatoma grew for approximately 2 weeks, developed central necrosis, ulcerated, and regressed. Growth of the line-10 hepatoma was suppressed when line-10 hepatoma cells were mixed with antigenically distinct line-1 hepatoma cells before id injection into syngeneic strain-2 guinea pigs. Mixture of line-10 with irradiated line-1 or viable strain-2 embryo cells did not inhibit tumor growth. Preimmunization of recipients to line-1 cells abrogated the suppression of tumor growth from mixtures of line-1 and line-10.

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Accession: 040587834

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PMID: 171435


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