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Long-term desipramine treatment attenuates clonidine-induced suppression of ventral tegmental self-stimulation

Long-term desipramine treatment attenuates clonidine-induced suppression of ventral tegmental self-stimulation

Life Sciences 36(5): 443-447

Long-term administration of the tricyclic antidepressant desipramine did not change the rate of self-stimulation responding in the A10 (ventral tegmental) area but significantly attenuated the suppressive effect of the selective alpha 2-adrenergic agonist clonidine on this behavior. These findings demonstrate an involvement of noradrenergic mechanisms in the regulation of ventral tegmental self-stimulation and further suggest that adaptive changes in inhibitory presynaptic noradrenergic receptors may be involved in desipramine's antidepressant effects.

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Accession: 040596613

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PMID: 3968971

DOI: 10.1016/0024-3205(85)90256-5

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