+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Long-term response to carbamazepine: a retrospective study



Long-term response to carbamazepine: a retrospective study



Journal of Clinical Psychopharmacology 8(2): 130-132



Carbamazepine is now used by many clinicians in the treatment of bipolar disorder (BD) refractory to standard treatments, including lithium and neuroleptics. Little information is yet available about the utility and efficacy of this novel treatment during long-term use. We carried out a retrospective study of 50 patients (34 with BD) who had received carbamazepine for the treatment of a psychotic disorder. Two-thirds (22) of the BD patients and two of the 16 patients with other diagnoses appeared to respond to carbamazepine acutely. However, follow-up 3 to 4 years later revealed that only eight patients (seven with BD) were still receiving the drug. In only two cases was the treating psychiatrist convinced that carbamazepine was clearly beneficial. Side effects, particularly hematological abnormalities, during both short- and long-term treatment were troublesome. Carbamazepine may only infrequently be useful in the long-term care of patients who fail to respond to standard treatment.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040600229

Download citation: RISBibTeXText

PMID: 3372707


Related references

Carbamazepine treatment of bipolar disorder: a retrospective evaluation of naturalistic long-term outcomes. Bmc Psychiatry 12: 47-47, 2013

Long term treatment in severe epilepsy institutionalized patients part 2 retrospective evaluation of carbamazepine. Penry, J Kiffin (Ed ) Epilepsy: The Eight International Symposium Dublin, Ireland, Sept , 12-15, 1976 Xv+414p Illus Raven Press: New York, N Y , Usa Isbn 0-89004-190-3 57-62, 1977

A retrospective case series of bipolar patients with adjunctive carbamazepine in long-term lithium treatment: evaluation of the effectiveness. Journal of Clinical Psychopharmacology 31(4): 538-540, 2012

Exaggerated acth response to h crh in two patients during long term carbamazepine treatment. Neuroendocrinology Letters: 218, 1987

Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg. Journal of Neurology Neurosurgery & Psychiatry 79(1): 93-96, 2008

Predictors of long-term response to abiraterone in patients with metastastic castration-resistant prostate cancer: a retrospective cohort study. Oncotarget 7(26): 40085-40094, 2016

Kinetics of the long-term antibody response after meningococcal C vaccination in patients with juvenile idiopathic arthritis: a retrospective cohort study. Annals of the Rheumatic Diseases 73(4): 728-734, 2014

Cyclosporin A response and dependence in children with acquired aplastic anaemia: a multicentre retrospective study with long-term observation follow-up. British Journal of Haematology 140(2): 197-205, 2008

Pregnancy is possible on long-term home parenteral nutrition in patients with chronic intestinal failure: Results of a long term retrospective observational study. Clinical Nutrition (): -, 2016

Long-term changes in graft height after maxillary sinus augmentation, onlay bone grafting, and combination of both techniques: a long-term retrospective cohort study. Clinical Oral Implants Research 25(2): E38-E46, 2015

An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction. Journal Of Clinical Immunology. 12(5): 335-340, 1992

Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg and of its predictive criteria in 40 patients. Journal of Neurology, Neurosurgery, and Psychiatry 79(1): 93-96, 2007

Complete pathological response after neoadjuvant treatment in locally advanced esophageal cancer predicts long term survival: a retrospective cohort study. International Journal of Surgery 12(6): 621-625, 2015

Microsomal epoxide hydrolase expression as a predictor of tamoxifen response in primary breast cancer: a retrospective exploratory study with long-term follow-up. Journal of Clinical Oncology 19(1): 3-9, 2001

A long-term low-dosage study of carbamazepine in trigeminal neuralgia. Headache 9(1): 64-72, 1969