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Lymphocyte reactivity against fetal antigens during the growth and regression of experimental tumors



Lymphocyte reactivity against fetal antigens during the growth and regression of experimental tumors



Biomedica Biochimica Acta 44(5): 805-811



Sensitization of lymphocytes occurs to fetal antigens during growth of malignant tumours. Sensitization was measured by the MEM-technique. Antigenic preparations, obtained by extraction with 3 M KCl of mouse fetal tissues were used. Growing tumors after allogenic transplantation of tumour cells gave rise to cellular sensitization. The disappearance of the tumours resulted in a decrease of the sensitization status. Lymphocytic sensitization to fetal antigens was evident in mice with intradermally growing tumors, too. After ligation, followed by regression of the tumours the sensitization became no longer detectable. The results show that tumour regression is associated with reversibility of cellular sensitization to fetal antigens.

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Accession: 040613484

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PMID: 4062925


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