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Lymphocyte-associated immune responses to canine distemper and measles viruses in distemper-infected gnotobiotic dogs

Krakowka, S.; Wallace, A.L.

American Journal of Veterinary Research 40(5): 669-672

1979


ISSN/ISBN: 0002-9645
PMID: 314249
Accession: 040613965

Cellular immune responses of peripheral blood lymphocytes to canine distemper virus and measles virus were determined in vaccinated or infected gnotobiotic dogs, using the technique of syncytia inhibition. Cross-reactivity between viruses was detected in both groups of dogs. Peak responses in vaccinated dogs occurred 11 days after vaccination and declined to base-line levels by 3 weeks, whereas responses in infected dogs were present 30 days after inoculation. Fractionation experiments with peripheral blood lymphocytes indicated that synctia inhibition is probably mediated by T lymphocytes.

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