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Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum


Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum



Journal of General Microbiology 115(1): 207-211



ISSN/ISBN: 0022-1287

PMID: 119032

DOI: 10.1099/00221287-115-1-207

The inhibitory effect of L-lysine on penicillin biosynthesis by Penicillium chrysogenum has been compared in a low-producing strain (Wis. 54-1255) and a high-producing strain (ASP-78). Lysine inhibited total penicillin synthesis to a similar extent in both strains. However, in the high-producing strain the onset of penicillin synthesis occurred even at a high lysine concentration, whereas in the low-producing strain lysine had to be depleted before penicillin production commenced.

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