+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells



Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells



Dakar Medical 34(1-4): 78-82



Activation of the respiratory metabolic channel (F.O.R.), responsible in part for the bactericidal effect, was measured in vitro by a chemoluminescence test on circulating phagocytes. All mycobacteria tested, except for Mycobacterium leprae, induced a significant response. Its effect on lepromatous leprosy pathology is a subject for discussion.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 040620074

Download citation: RISBibTeXText

PMID: 2518818


Related references

Induction of macrophage unresponsiveness to interferon gamma by mycobacterium leprae constituents. International Journal of Leprosy & Other Mycobacterial Diseases 56(4): 683-684, 1988

A comparative study on the activation of j 774 macrophage like cells by gamma interferon 1 25 dihydroxyvitamin d 3 and lipopeptide rp 56142 ability to kill intracellularly multiplying mycobacterium tuberculosis and mycobacterium avium. Zentralblatt fuer Bakteriologie 273(3): 344-361, 1990

Phenolic glycolipid 1 from mycobacterium leprae inhibits oxygen free radical production by human mononuclear cells. Research in Immunology 140(9): 847-856, 1989

Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon. Infection and Immunity 55(2): 446-450, 1987

Protection against pulmonary infection with Klebsiella pneumoniae in mice by interferon-gamma through activation of phagocytic cells and stimulation of production of other cytokines. Journal of Medical Microbiology 50(11): 959-964, 2001

Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages. Cytokine 43(2): 124-131, 2008

Human phagocyte oxidative burst activation by BCG, M. leprae, and atypical mycobacteria: defective activation by M. leprae is not reversed by interferon gamma. Cellular Immunology 124(1): 168-174, 1989

Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation. Infection and Immunity 74(1): 213-224, 2006

Effect of multiple interferon gamma injections on the disposal of Mycobacterium leprae. Proceedings of the National Academy of Sciences of the United States of America 86(20): 8073-8077, 1989

Mycobacterium leprae fails to stimulate murine macrophage post phagocytic metabolic burst. Clinical Research 31(4): 818A, 1983

Mycobacterium leprae-induced interferon-gamma production by household contacts of leprosy patients: association with the development of active disease. Journal of Infectious Diseases 164(5): 990-993, 1991

Failure of mycobacterium leprae to stimulate macrophage post phagocytic chemi luminescence and glucose oxidation. Clinical Research 30(4): 778A, 1982

Gamma interferon, but not Mycobacterium leprae, induces major histocompatibility class II antigens on cultured rat Schwann cells. Journal of Neurocytology 16(2): 281-287, 1987

Effect of mycobacterium leprae phenolic glycolipid i on interferon gamma augmentation of monocyte oxidative responses. International Journal of Leprosy & Other Mycobacterial Diseases 58(2): 342-346, 1990

Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD. Clinical and Experimental Immunology 114(2): 196-203, 1998