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Mast cell and anaphylactic antibody responses in inbred rats to syngeneic fibrosarcomas



Mast cell and anaphylactic antibody responses in inbred rats to syngeneic fibrosarcomas



International Archives of Allergy and Applied Immunology 49(5): 627-631



The mast cell content of sarcomata induced chemically in inbred rats showed wide variation. After first passage into a normal syngeneic recipient, primary tumours which were heavily infiltrated showed a complete absence of mast cells. Moreover, detectable anaphylactic antibody to passaged tumours was only occasionally detected. An important immunological role for the IgE/mast cell system in host-tumour defence is not supported.

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Accession: 040644603

Download citation: RISBibTeXText

PMID: 1176186

DOI: 10.1159/000231444


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