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Mechanism of recovery from acute virus infection. II. Effect of treatment of mice with cyclosporin A on their ability to eliminate the lymphocytic choriomeningitis virus



Mechanism of recovery from acute virus infection. II. Effect of treatment of mice with cyclosporin A on their ability to eliminate the lymphocytic choriomeningitis virus



Medical Microbiology and Immunology 174(4): 187-196



Illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin A (CSA), although the virus multiplied extensively in all major organs. Concentrations remained high as long as the drug was administered but declined when the treatment was discontinued; also, cytotoxic T lymphocytes appeared. Virus elimination was slower and cytotoxic T cell activity lower than in mice not previously treated with CSA.

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Accession: 040659438

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PMID: 3877860

DOI: 10.1007/bf02123695


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