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Metastasis-stimulating activity in the mouse uterus

Metastasis-stimulating activity in the mouse uterus

Biology of Reproduction 36(3): 701-708

ISSN/ISBN: 0006-3363

PMID: 3593842

DOI: 10.1095/biolreprod36.3.701

Mouse uterine luminal proteins are thought to play important roles in inducing diapausing blastocysts to implant into the uterine wall. Employing a syngeneic teratocarcinoma cell line (402AX), we demonstrate that neoplastic cells are better able to invade and metastasize if they are coinjected with uterine fluid from pregnant or estrogen-primed mice. This metastasizing activity of uterine fluid was partially purified by using disc polyacrylamide electrophoresis and gel filtration chromatography. Preliminary experiments indicate that the post-albumin and albumin bands contain most of the bioactivity. Furthermore, these bands contain smaller molecular weight proteins (less than 14,000) than can be separated by detergent and mild acetic acid (0.1 N) treatment.

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Accession: 040687033

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