+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Microencapsulated charcoal hemoperfusion: a possible therapeutic adjunct in digoxin toxicity



Microencapsulated charcoal hemoperfusion: a possible therapeutic adjunct in digoxin toxicity



Journal of Dialysis 1(4): 367-377



Attempts to remove substantial quantities of digoxin by either peritoneal or hemodialysis, have been unsuccessful due to their low clearance rate. The present study determined the in-vivo clearance rate for digoxin of a single microcapsule of 300 gm of activated charcoal. The clearance rate was 55 +/- 5 ml/min (mean +/- SEM) in the first hour and 48.4 +/- 4 ml/min in the second; these values are approximately five-fold higher than with other dialysis techniques. No evidence of a post-dialysis rebound increase in serum digoxin levels was found, implying that peripheral tissues can rapidly release digoxin to the diminishing serum pool. Preliminary data obtained suggest a beneficial effect on arrhythmias and lowering of the myocardial to serum rate of digoxin after hemoperfusion.

(PDF emailed within 0-6 h: $19.90)

Accession: 040698600

Download citation: RISBibTeXText

PMID: 608859

DOI: 10.3109/08860227709038427


Related references

Advanced digoxin toxicity in renal failure: treatment with charcoal hemoperfusion. Southern Medical Journal 72(3): 279-281, 1979

Charcoal-activated hemoperfusion--an important adjunct therapeutic method in severe poisoning. Die Medizinische Welt 27(16): 752-757, 1976

Artificial liver: the effect of ACAC microencapsulated charcoal hemoperfusion on fulminant hepatic failure. Artificial Organs 1(1): 76-83, 1977

Digoxin and digitoxin elimination in man by charcoal hemoperfusion. Klinische Wochenschrift 56(23): 1179-1183, 1978

Comparison of XAD-4 and charcoal hemoperfusion for removal of digoxin and digitoxin. Kidney International. Supplement 10: S101-S105, 1980

Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion. Clinical Toxicology 15(4): 437-446, 1979

Clinical evaluation of the clearance profiles of a portable, compact, dialysate-free system incorporating microencapsulated charcoal hemoperfusion for blood purification with ultrafiltration for fluid removal. Journal of Dialysis 1(3): 239-259, 1977

Charcoal hemoperfusion and methotrexate toxicity. Nephron 58(3): 378-378, 1991

Hemoperfusion in the management of digoxin toxicity. JAMA 240(25): 2736-2737, 1978

Charcoal hemoperfusion treatment of severe theophylline toxicity. Australian and New Zealand Journal of Medicine 15(1): 75-77, 1985

Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?. Indian Journal of Critical Care Medicine 20(2): 123-125, 2016

Treatment of ibuprofen toxicity with serial charcoal hemoperfusion and hemodialysis in a dog. Journal of Veterinary Emergency and Critical Care 26(6): 787-792, 2016

Hemoperfusion hemodialysis treatment for digoxin toxicity in a uremic patient. Current Therapeutic Research 43(1): 27-31, 1988

Hemodialysis as an alternative to charcoal hemoperfusion for treatment of acute carbamazepine toxicity. Journal of the American Society of Nephrology 14(Abstracts Issue): 817A, November, 2003

Therapeutic efficacy of charcoal hemoperfusion in patients with acute severe dichlorvos poisoning. Acta Pharmacologica Sinica 25(1): 15-21, 2004