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Microencapsulated charcoal hemoperfusion: a possible therapeutic adjunct in digoxin toxicity

Microencapsulated charcoal hemoperfusion: a possible therapeutic adjunct in digoxin toxicity

Journal of Dialysis 1(4): 367-377

Attempts to remove substantial quantities of digoxin by either peritoneal or hemodialysis, have been unsuccessful due to their low clearance rate. The present study determined the in-vivo clearance rate for digoxin of a single microcapsule of 300 gm of activated charcoal. The clearance rate was 55 +/- 5 ml/min (mean +/- SEM) in the first hour and 48.4 +/- 4 ml/min in the second; these values are approximately five-fold higher than with other dialysis techniques. No evidence of a post-dialysis rebound increase in serum digoxin levels was found, implying that peripheral tissues can rapidly release digoxin to the diminishing serum pool. Preliminary data obtained suggest a beneficial effect on arrhythmias and lowering of the myocardial to serum rate of digoxin after hemoperfusion.

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Accession: 040698600

Download citation: RISBibTeXText

PMID: 608859

DOI: 10.3109/08860227709038427

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