Mitochondrial pyruvate carrier--a possible link between gluconeogenesis and ketogenesis in the liver
Kümmel, L.
Bioscience Reports 7(7): 593-597
1987
ISSN/ISBN: 0144-8463
PMID: 3689883
DOI: 10.1007/bf01119777
Accession: 040708609
Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.
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