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Modelling binary data from a three-period cross-over trial

Modelling binary data from a three-period cross-over trial

Statistics in Medicine 6(5): 555-564

A new method of analysing binary data from a three-treatment, three-period cross-over trial is described. This method is based on a log-linear model and mirrors the analysis of continuous data. It is an extension of the method we introduced recently for the analysis of binary data from a two-treatment, two-period cross-over trial. We illustrate our method using data from a trial which compared two analgesics and a placebo for the relief of primary dysmenorrhea.

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Accession: 040712614

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PMID: 3659665

DOI: 10.1002/sim.4780060504

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