Section 41
Chapter 40,718

Modifying action of levamisole on the course of adjuvant-induced polyarthritis in rats

Brajczewska-Fischer, W.; Szpilman, H.; Ryzèwska, A.

Archivum Immunologiae et Therapiae Experimentalis 27(1-2): 241-246


ISSN/ISBN: 0004-069X
PMID: 444037
Accession: 040717584

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Treatment of August rats with levamisole (L-tetramisole) distinctly depressed the development and the course of adjuvant-induced polarthritis (A-pa). The depressing activity of the drug was dose-dependent. However, spontaneous stimulation of lymphocytes from A-pa rats treated with levamisole was decreased only after the first 7 days of treatment. Moreover, these lymphocytes showed no changes in PHA-reactivity in comparison with untreated animals. It was concluded that levamisole in some circumstances may show immunosuppressive activity; however, it did not seem to act directly on lymphocytes.

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