Modifying action of levamisole on the course of adjuvant-induced polyarthritis in rats
Brajczewska-Fischer, W.; Szpilman, H.; Ryzèwska, A.
Archivum Immunologiae et Therapiae Experimentalis 27(1-2): 241-246
ISSN/ISBN: 0004-069X PMID: 444037 Accession: 040717584
Treatment of August rats with levamisole (L-tetramisole) distinctly depressed the development and the course of adjuvant-induced polarthritis (A-pa). The depressing activity of the drug was dose-dependent. However, spontaneous stimulation of lymphocytes from A-pa rats treated with levamisole was decreased only after the first 7 days of treatment. Moreover, these lymphocytes showed no changes in PHA-reactivity in comparison with untreated animals. It was concluded that levamisole in some circumstances may show immunosuppressive activity; however, it did not seem to act directly on lymphocytes.