+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Modulation of glucagon actions by phorbol myristate acetate in isolated hepatocytes. Effect of hypothyroidism

Modulation of glucagon actions by phorbol myristate acetate in isolated hepatocytes. Effect of hypothyroidism

Cellular Signalling 2(3): 235-243

ISSN/ISBN: 0898-6568

PMID: 2169291

DOI: 10.1016/0898-6568(90)90051-b

Phorbol myristate acetate (PMA) inhibits glucagon-stimulated cyclic AMP accumulation and shifts to the right the dose-response curve to glucagon for ureagenesis. In cells from hypothyroid rats the effect of PMA on glucagon-stimulated ureagenesis was much more pronounced, but its effect on cyclic AMP accumulation was similar to that observed in the control cells. The stimulations of ureagenesis by the glucagon analogue THG and dibutyryl cyclic AMP (But2-cAMP) were also diminished by PMA, to a greater extent in cells from hypothyroid rats than in those from euthyroid rats. PMA inhibited the increases in cytoplasmic [Ca2+] induced by glucagon. THG or But2-cAMP; the effect of PMA was much more marked in cells from hypothyroid rats than in the controls. Treatment of the cells with glucagon or THG increased the production of citrulline by subsequently isolated mitochondria, whereas PMA diminished their effects. The results suggest that PMA alters glucagon actions at least at two levels; (i) cyclic AMP production and (ii) elevation of cytosol calcium. The increased sensitivity to PMA of some glucagon effects in hypothyroid rats seems to be related to the latter action.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 040718971

Download citation: RISBibTeXText

Related references

Effect of glucagon and phorbol myristate acetate on oxidative demethylation and lipid peroxidation in isolated hepatocytes. Acta Biochimica Polonica 38(2): 251-263, 1991

4 beta-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes. Biochemical Journal 238(3): 737-743, 1986

4 beta phorbol 12 myristate 13 acetate attenuates the glucagon induced increase in cytoplasmic free calcium concentration in isolated rat hepatocytes. Biochemical Journal 238(3): 737-744, 1986

Hormonal modulation of c-fos expression in isolated hepatocytes. Effects of angiotensin II and phorbol myristate acetate on transcription and mRNA degradation. Biochimica et Biophysica Acta 1310(2): 217-222, 1996

Modulation of Gs activity by phorbol myristate acetate in rat hepatocytes. American Journal of Physiology 260(2 Pt 1): C259-C265, 1991

Modulation of gs activity by phorbol myristate acetate in rat hepatocytes. FASEB Journal 4(7): A1777, 1990

Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate. Biochemical Journal (London 1906) 233(1): 287-289, 1986

Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate. Biochemical Journal 233(1): 287-289, 1986

Stimulation of phosphatidylethanolamine synthesis in isolated rat hepatocytes by phorbol 12-myristate 13-acetate. Biochimica et Biophysica Acta 922(2): 184-190, 1987

Phorbol-12-myristate-13-acetate effect on cyclic adenosine 3',5'-monophosphate levels in mouse skin and inhibition of phorbol-myristate-acetate-promoted tumorigenesis by theophylline. Cancer Research 34(12): 3446-3455, 1974

Angiotensin ii and phorbol myristate acetate pma induce protooncogene expression in isolated rat hepatocytes. FASEB Journal 6(5): A1639, 1992

Comparison of the action of interleukin 6 phorbol myristate acetate and glucagon on the acute phase protein production and amino acid uptake by cultured rat hepatocytes. Sehgal, P B , G Grieninger And G Tosato (Ed ) Annals Of The New York Academy Of Sciences, Vol 557 Regulation Of The Acute Phase And Immune Responses: Interleukin-6; Conference, New York, New York, Usa, December 12-14, 1988 Xvi+583p The New York Academy Of Sciences: New York, New York, Usa Illus 506-508, 1989

Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate. Journal of Biological Chemistry 261(24): 11056-11063, 1986

Stimulation of fatty acid synthesis by 4 beta-phorbol-12-myristate-13-acetate in isolated rat hepatocytes. Lipids 21(5): 366-367, 1986

The activation of pyruvate dehydrogenase by glucagon in hepatocytes is diminished by phorbol myristate acetate: a role for cytoplasmic calcium in dehydrogenase regulation. Advances in Experimental Medicine and Biology 232: 245-247, 1988