+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol



Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol



European Journal of Clinical Pharmacology 11(2): 125-128



Lumbar cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline (4-hydroxy-3-methoxyphenyl glycol, HMPG), serotonin (5-hydroxyindoleacetic acid) and dopamine (homovanillic acid) were measured before and during the administration of clonidine or alprenolol to hypertensive patients. The noradrenaline receptor stimulant clonidine significantly decreased the CSF level of HMPG, but there was no consistent change in the concentration of serotonin or dopamine metabolites. Patients on alprenolol showed no change in the levels of these metabolites in CSF.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 040729143

Download citation: RISBibTeXText

PMID: 837965

DOI: 10.1007/bf00562903


Related references

Effects of oral clonidine premedication on concentrations of cortisol and monoamine neurotransmitters and their metabolites in cerebrospinal fluid and plasma. Acta Anaesthesiologica Scandinavica 33(2): 137-141, 1989

Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin. European Journal of Clinical Pharmacology 18(5): 399-401, 1980

Changes in cerebrospinal fluid monoamine metabolites during long-term antidepressant treatment. European Neuropsychopharmacology 10(5): 341-349, 2000

Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramine. Clinical Pharmacology and Therapeutics 21(2): 201-207, 1977

Monoamine metabolites in cerebrospinal fluid of depressed patients during treatment with mianserin or amitriptyline. Journal of Affective Disorders 4(3): 219-226, 1982

Lithium carbonate treatment of mania. Cerebrospinal fluid and urinary monoamine metabolites and treatment outcome. Archives of General Psychiatry 44(4): 345-354, 1987

Effect of ischemia on monoamine metabolism. Brain monoamine metabolites in cerebrospinal fluid of patients with recent cerebral infarction. Neuropatologia Polska 20(1-2): 97-105, 1982

Biochemical effects of antidepressant treatment--studies of monoamine metabolites in cerebrospinal fluid and platelet [3H]imipramine binding. Ciba Foundation Symposium 123: 57-83, 1986

Corticotropin releasing factor like immunoreactivity in cerebrospinal fluid in normal controls and major depression relationship to cerebrospinal fluid monoamine metabolites dexamethasone suppression test and trh stimulation test results. Society for Neuroscience Abstracts 10(2): 1093, 1984

Intravenous probenecid loading. Effects on plasma and cerebrospinal fluid probenecid levels and on monoamine metabolites in cerebrospinal fluid. Neurology 26(10): 992-996, 1976

Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid. Acta Psychiatrica Scandinavica 79(6): 586-596, 1989

Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3H-imipramine binding and serotonin uptake and concentration in major depressive disorder. Acta Psychiatrica Scandinavica 83(2): 125-133, 1991

Pterins and monoamine metabolites in cerebrospinal fluid. Curtius, H -C , N Blau And R A Levine (Ed ) Unconjugated Pterins And Related Biogenic Amines; First International Workshop, Flims, Switzerland, February 28-March 7, Xiv+397p Walter De Gruyter And Co : Berlin, West Germany; New York, New York, Usa Illus 367-374, 1987

Purine and monoamine metabolites in cerebrospinal fluid. Advances in Experimental Medicine and Biology 195 Pt B: 53-56, 1986

Cerebrospinal fluid monoamine metabolites and suicide. Nordic Journal of Psychiatry 61(3): 233-234, 2007