Section 41
Chapter 40,730

Monoclonal 'internal image' anti-idiotypic antibodies of hepatitis B surface antigen

Thanavala, Y.M.; Bond, A.; Tedder, R.; Hay, F.C.; Roitt, I.M.

Immunology 55(2): 197-204


ISSN/ISBN: 0019-2805
PMID: 2408999
Accession: 040729506

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The hypervariable regions of the immunoglobulin molecule which function as the antigen-combining site are, themselves, capable of provoking an antibody response. These antigenic determinants on the immunoglobulin are termed the 'idiotype', and antibodies directed against them 'anti-idiotype'. In circumstances where there is a close complementarity of shape between antigen and idiotype, and subsequently between idiotype and anti-idiotype, it would be predicted that anti-idiotype would be like an 'internal image' of the antigen. Starting with a monoclonal antibody (idiotype) to the protective a determinant of the hepatitis B surface antigen (HBsAg), we have succeeded in raising two monoclonal anti-idiotypes which mimic HBsAg in their ability to bind polyclonal antibodies to HBsAg produced in a variety of species. These internal image anti-idiotypes may provide a strategy for immunization without the need for antigen.

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