N-methyl-D-aspartate receptors mediate tonic vasodepressor control in the caudal ventrolateral medulla of the rat

Kubo, T.; Kihara, M.

Brain Research 451(1-2): 366-370

1988


ISSN/ISBN: 0006-8993
PMID: 2855214
DOI: 10.1016/0006-8993(88)90786-x
Accession: 040767895

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Abstract
Microinjections of N-methyl-D-aspartate (NMDA) into the caudal ventrolateral medulla of the rat led to a decrease in arterial pressure whereas 2-amino-5-phosphonovalerate injected bilaterally into this region produced hypertension and blocked the depressor effect of aortic nerve stimulation. High K+ stimulation via push-pull cannula caused a calcium-dependent release of endogenous glutamate from the region. These results provide evidence for the NMDA receptor system involved in tonic vasodepressor control in the rat caudal ventrolateral medulla.